ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Aphrodisin

Intermolecular
Cysteine 58 and cysteine 58
Intramolecular
Cysteine 54 and cysteine 58
A redox-regulated disulphide may form between two units of Aphrodisin at cysteines 58 and 58 (42 and 42 respectively in this structure).

Details

Redox score ?
83
PDB code
1e5p
Structure name
crystal structure of aphrodisin, a sex pheromone from female hamster
Structure deposition date
2000-07-28
Thiol separation (Å)
3
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide A name
Aphrodisin
Peptide B name
Aphrodisin
Peptide A accession
P09465
Peptide B accession
P09465
Peptide A residue number
58
Peptide B residue number
58

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Aphrodisin between cysteines 54 and 58 (38 and 42 respectively in this structure).

Details

Redox score ?
87
PDB code
1e5p
Structure name
crystal structure of aphrodisin, a sex pheromone from female hamster
Structure deposition date
2000-07-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
P09465
Residue number A
54
Residue number B
58
Peptide name
Aphrodisin

Ligandability

Cysteine 54 of Aphrodisin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Aphrodisin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: